![]() ![]() Therefore, the current investigation was undertaken to evaluate the effects of varying the stimulating current intensity, pulse width, electrode placement, and electrode polarity on evoked neuromuscular responses and pain. Also, pharmacodynamic studies of new muscle relaxant agents (and their comparison with established agents) rely on measurements of evoked responses that are very sensitive to even minor fluctuations in stimulus intensity. Neurostimulation is increasingly used in nonoperative settings in unanesthetized patients or volunteers (postoperative care and intensive care units and clinical research centers), where the effects of neurostimulation intensity and efficiency may directly impact patient comfort. Such information is important in both clinical and investigative settings. However, the relative effects of these factors have not been explored over the range of current intensities and pulse widths that may be used clinically, and their effects on subjective responses (pain) have not been evaluated. Electrode placement and polarity orientation also may affect the magnitude of the evoked response. ![]()
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